Ass1^tm1Bay
Targeted Allele Detail

Summary

• Symbol: Ass1^tm1Bay
• Name: argininosuccinate synthetase 1; targeted mutation 1, Baylor College of Medicine
• MGI ID: MGI:1857131
• Synonyms: Ass^-
• Gene: Ass1 Location: Chr2:31360282-31410682 bp, + strand Genetic Position: Chr2, 21.81 cM
• Alliance: Ass1^tm1Bay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:18326
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 4 of the gene. Activity assays in liver extracts from homozygous mice demostrated the absence of the functional protein. (J:18326)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ass1 Mutation: 58 strains or lines available

References

• Original: J:18326 Patejunas G, et al., Generation of a mouse model for citrullinemia by targeted disruption of the argininosuccinate synthetase gene. Somat Cell Mol Genet. 1994 Jan;20(1):55-60
• All: 5 reference(s)