Atm^tm1Awb
Targeted Allele Detail

Summary

• Symbol: Atm^tm1Awb
• Name: ataxia telangiectasia mutated; targeted mutation 1, Anthony Wynshaw Boris
• MGI ID: MGI:1857132
• Synonyms: Atm-, ATM^-, Atm^ins5790neo, Atm^tm1Awbl
• Gene: Atm Location: Chr9:53350449-53448040 bp, - strand Genetic Position: Chr9, 29.12 cM, cytoband C-D
• Alliance: Atm^tm1Awb page

Oxidated stress in the brain of Atm^tm1Awb/Atm^tm1Awb mice indicated by increased levels of heme oxygenase

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34193
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neomycin cassette was inserted into position 5979 of the Atm gene. This mutation results in a truncated protein, and the position of the mutation corresponds to the location of truncation mutations known to exist in humans. (J:34193)

Disease models

Expression

In Mice Carrying this Mutation:	39 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Atm^tm1Awb

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Atm Mutation: 170 strains or lines available

References

• Original: J:34193 Barlow C, et al., Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell. 1996 Jul 12;86(1):159-71
• All: 237 reference(s)