Bcl2^tm1Sjk
Targeted Allele Detail

Summary

• Symbol: Bcl2^tm1Sjk
• Name: B cell leukemia/lymphoma 2; targeted mutation 1, Stanley J Korsmeyer
• MGI ID: MGI:1857134
• Synonyms: Bcl-2^-, BclII^tm1Sjk
• Gene: Bcl2 Location: Chr1:106465908-106642004 bp, - strand Genetic Position: Chr1, 49.76 cM
• Alliance: Bcl2^tm1Sjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:15224
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.1 kb genomic fragment containing all of the coding region of exon 3 was replaced with a neomycin selection cassette. The authors state that no full length or truncated protein was detected in vitro or in vivo (data not shown). (J:15224)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	22 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcl2 Mutation: 41 strains or lines available

References

• Original: J:15224 Veis DJ, et al., Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell. 1993 Oct 22;75(2):229-40
• All: 42 reference(s)