Bdnf^tm1Jae
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm1Jae
• Name: brain derived neurotrophic factor; targeted mutation 1, Rudolf Jaenisch
• MGI ID: MGI:1857136
• Synonyms: BDNF^-, BDNF-KO
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm1Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17123
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A part of exon 5 of the gene was deleted and replaced by a neomycin cassette. This deletion left 49 and 30 amino acids in the N and C termini, respectively. Northern blot analysis on RNA derived from cerebral cortex showed that no detectable transcript is expressed from this allele. (J:17123)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	64 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:17123 Ernfors P, et al., Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature. 1994 Mar 10;368(6467):147-50
• All: 151 reference(s)