Bmp4^tm1Blh
Targeted Allele Detail

Summary

• Symbol: Bmp4^tm1Blh
• Name: bone morphogenetic protein 4; targeted mutation 1, Brigid L Hogan
• MGI ID: MGI:1857137
• Synonyms: Bmp4^-, Bmp4^delta, Bmp4^tm1, Bmp-4^tm1blh
• Gene: Bmp4 Location: Chr14:46620982-46628126 bp, - strand Genetic Position: Chr14, 23.95 cM
• Alliance: Bmp4^tm1Blh page

Anterior eye segment abnormalities in Bmp4^tm1Blh/Bmp4⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28717
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing all of the coding sequence of the gene after the seventh codon of exon 1. An oligonucleotide encoding a stop codon in all three reading frames was also inserted into exon 2. (J:28717)

Disease models

Expression

In Mice Carrying this Mutation:	90 assay results
In Structures Affected by this Mutation:	40 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Bmp4 Mutation: 23 strains or lines available

References

• Original: J:28717 Winnier G, et al., Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 1995 Sep 1;9(17):2105-16
• All: 43 reference(s)