Btk^tm1Wk
Targeted Allele Detail

Summary

• Symbol: Btk^tm1Wk
• Name: Bruton agammaglobulinemia tyrosine kinase; targeted mutation 1, Wasif Kahn
• MGI ID: MGI:1857138
• Synonyms: Btk-, Btk-kin^-/GL, Btk^M
• Gene: Btk Location: ChrX:133443085-133484319 bp, - strand Genetic Position: ChrX, 56.18 cM
• Alliance: Btk^tm1Wk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28968
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exons 13 and 14 was replaced with a neomycin resistance cassette. These sequences encode the beginning of the kinase domain. (J:28968)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Btk Mutation: 21 strains or lines available

References

• Original: J:28968 Khan WN, et al., Defective B cell development and function in Btk-deficient mice. Immunity. 1995 Sep;3(3):283-99
• All: 83 reference(s)