Cd4^tm1Knw
Targeted Allele Detail

Summary

• Symbol: Cd4^tm1Knw
• Name: CD4 antigen; targeted mutation 1, Barbara B Knowles
• MGI ID: MGI:1857143
• Synonyms: CD4-, CD4D
• Gene: Cd4 Location: Chr6:124841655-124865184 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Cd4^tm1Knw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48775
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance gene was inserted into exon 5. (J:48775)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Cd4 Mutation: 85 strains or lines available

References

• Original: J:48775 McCarrick JW 3rd, et al., Positive-negative selection gene targeting with the diphtheria toxin A-chain gene in mouse embryonic stem cells. Transgenic Res. 1993 Jul;2(4):183-90
• All: 31 reference(s)