Cd40lg^tm1Imx
Targeted Allele Detail

Summary

• Symbol: Cd40lg^tm1Imx
• Name: CD40 ligand; targeted mutation 1, Immunex
• MGI ID: MGI:1857145
• Synonyms: CD154^-, CD40L-, CD40LKO, Tnfsf5^tm1Imx
• Gene: Cd40lg Location: ChrX:56257503-56269402 bp, + strand Genetic Position: ChrX, 31.21 cM
• Alliance: Cd40lg^tm1Imx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21137
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were replaced with a neomycin cassette. Homozygous mutant animals fail to express functional protein on the cell surface. (J:21137)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Cd40lg Mutation: 17 strains or lines available

References

• Original: J:21137 Renshaw BR, et al., Humoral immune responses in CD40 ligand-deficient mice. J Exp Med. 1994 Nov 1;180(5):1889-900
• All: 168 reference(s)