Cdkn1b^tm1Mlf
Targeted Allele Detail

Summary

• Symbol: Cdkn1b^tm1Mlf
• Name: cyclin dependent kinase inhibitor 1B; targeted mutation 1, Matthew Fero
• MGI ID: MGI:1857146
• Synonyms: Cdkln1^btm1Mlf, p27-, p27^Kip1-, p27^Kip1, p27^kip1-null
• Gene: Cdkn1b Location: Chr6:134897364-134902476 bp, + strand Genetic Position: Chr6, 65.77 cM
• Alliance: Cdkn1b^tm1Mlf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33400
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of the entire coding region of the Cdkn1b gene with a neomycin cassette. (J:33400)

Disease models

Expression

In Mice Carrying this Mutation:	34 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn1b^tm1Mlf

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cdkn1b Mutation: 26 strains or lines available

References

• Original: J:33400 Fero ML, et al., A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell. 1996 May 31;85(5):733-44
• All: 147 reference(s)