Cd5^tm1Cgn
Targeted Allele Detail

Summary

• Symbol: Cd5^tm1Cgn
• Name: CD5 antigen; targeted mutation 1, University of Cologne
• MGI ID: MGI:1857148
• Synonyms: CD5^-, CD5⁰, CD5T
• Gene: Cd5 Location: Chr19:10695471-10716390 bp, - strand Genetic Position: Chr19, 7.16 cM
• Alliance: Cd5^tm1Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:19317
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin gene replaced part of exon 7, which encodes the transmembrane domain. An additional frameshift mutation was introduced into exon 3. Flow cytometry analysis on cells derived from thymus, spleen and the peritoneal cavity of homozygous mice confirmed that no detectable protein was expressed from this allele. (J:19317)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd5 Mutation: 36 strains or lines available

References

• Original: J:19317 Tarakhovsky A, et al., Lymphocyte populations and immune responses in CD5-deficient mice. Eur J Immunol. 1994 Jul;24(7):1678-84
• All: 25 reference(s)