Cga^tm1Sac
Targeted Allele Detail

Summary

• Symbol: Cga^tm1Sac
• Name: glycoprotein hormones, alpha subunit; targeted mutation 1, Sally A Camper
• MGI ID: MGI:1857152
• Synonyms: TSHalpha -
• Gene: Cga Location: Chr4:34893779-34907370 bp, + strand Genetic Position: Chr4, 16.86 cM
• Alliance: Cga^tm1Sac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28450
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into the third exon. In situ hybridization and RT-PCR experiments confirmed that the transcript was not present in pituitary of homozygous mice (data not shown). (J:28450)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cga Mutation: 16 strains or lines available

References

• Original: J:28450 Kendall SK, et al., Targeted disruption of the pituitary glycoprotein hormone alpha-subunit produces hypogonadal and hypothyroid mice. Genes Dev. 1995 Aug 15;9(16):2007-19
• All: 8 reference(s)