Cxcr2^tm1Mwm
Targeted Allele Detail

Summary

• Symbol: Cxcr2^tm1Mwm
• Name: C-X-C motif chemokine receptor 2; targeted mutation 1, Mark Moore
• MGI ID: MGI:1857153
• Synonyms: Cmkar2^tm1Mwm, Cmkar^tm1Mwm, CXCR^-, CXCR2 -, CXCR2-, Il8rb^tm1Mwm, mCXCR^-, mCXCR2^-, mIL-8Rh-, mIL-8Rh KO
• Gene: Cxcr2 Location: Chr1:74193153-74200405 bp, + strand Genetic Position: Chr1, 38.41 cM
• Alliance: Cxcr2^tm1Mwm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:19570
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin selection cassette replaced the entire coding sequence of the gene. (J:19570)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Cxcr2 Mutation: 30 strains or lines available

References

• Original: J:19570 Cacalano G, et al., Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science. 1994 Jul 29;265(5172):682-4
• All: 159 reference(s)