Col1a1^tm1Jae
Targeted Allele Detail

Summary

• Symbol: Col1a1^tm1Jae
• Name: collagen, type I, alpha 1; targeted mutation 1, Rudolf Jaenisch
• MGI ID: MGI:1857154
• Synonyms: Col1a1^r, Col1a1^tmJae, Col^R, mutation IV, rr
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^tm1Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:26504
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Several point mutations were introduced into the sequences encoding the collagenase cleavage domain by a "hit and run" targeting strategy. These mutations resulted in substitutions of proline for glutamine-774 and alanine-777 and methionine for isoleucine-776 in the encoded protein. (J:17514)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 163 strains or lines available

References

• Original: J:26504 Liu X, et al., A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J Cell Biol. 1995 Jul;130(1):227-37
• All: 27 reference(s)