Gzmb^tm1Ley
Targeted Allele Detail

Summary

• Symbol: Gzmb^tm1Ley
• Name: granzyme B; targeted mutation 1, Timothy J Ley
• MGI ID: MGI:1857156
• Synonyms: Granzyme B-, GrB KO, GrzB-, gzmB-, Gzmb-, Gzmb^-/+PGK-neo
• Gene: Gzmb Location: Chr14:56496295-56499717 bp, - strand Genetic Position: Chr14, 28.19 cM, cytoband D3
• Alliance: Gzmb^tm1Ley page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23560
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced a 350bp AvrII fragment starting within the 5' untranslated region (22 bp upstream from the initiation codon), extending through exon 1 and part of intron 1. (J:23560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Gzmb Mutation: 29 strains or lines available

References

• Original: J:23560 Heusel JW, et al., Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell. 1994 Mar 25;76(6):977-87
• All: 107 reference(s)