Dnmt1^tm1Jae
Targeted Allele Detail

Summary

• Symbol: Dnmt1^tm1Jae
• Name: DNA methyltransferase 1; targeted mutation 1, Rudolf Jaenisch
• MGI ID: MGI:1857157
• Synonyms: Dmntⁿ, Dnmt1^N, Dnmt^N, MTase(-), Mtaseⁿ
• Gene: Dnmt1 Location: Chr9:20818501-20871084 bp, - strand Genetic Position: Chr9, 7.66 cM
• Alliance: Dnmt1^tm1Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:1157
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of 900 bp, including the translation start site, with a neomycin cassette. This is a hypomorphic allele; enzyme activity levels have dropped to approximately 30% of the normal value. (J:1157)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	64 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Dnmt1^tm1Jae

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dnmt1 Mutation: 112 strains or lines available

References

• Original: J:1157 Li E, et al., Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. 1992 Jun 12;69(6):915-26
• All: 34 reference(s)