Edn3^tm1Ywa
Targeted Allele Detail

Summary

• Symbol: Edn3^tm1Ywa
• Name: endothelin 3; targeted mutation 1, Masashi Yanagisawa
• MGI ID: MGI:1857160
• Synonyms: edn3
• Gene: Edn3 Location: Chr2:174602412-174625835 bp, + strand Genetic Position: Chr2, 98.1 cM
• Alliance: Edn3^tm1Ywa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22207
• Parent Cell Line: JH1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into the middle of exon 2, deleting the mature Edn3-encoding portion of the exon. No mature Edn3 protein was detected by EIA of kidney, brain, or intestine from homozygous mutant mice. (J:22207)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Edn3 Mutation: 24 strains or lines available

References

• Original: J:22207 Baynash AG, et al., Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell. 1994 Dec 30;79(7):1277-85
• All: 9 reference(s)