Klf1^tm1Sho
Targeted Allele Detail

Summary

• Symbol: Klf1^tm1Sho
• Name: Kruppel-like transcription factor 1 (erythroid); targeted mutation 1, Stuart Orkin
• MGI ID: MGI:1857162
• Synonyms: EKLF^-
• Gene: Klf1 Location: Chr8:85628611-85631920 bp, + strand Genetic Position: Chr8, 41.3 cM
• Alliance: Klf1^tm1Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25651
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a portion of intron 2 and exon 2, which encodes the zinc-finger DNA-binding domain of the protein. No stable RNA for the targeted gene was detected by RNase protection using RNA from homozygous mutant embryos. (J:25651)

Disease models

Expression

In Mice Carrying this Mutation:

52048 assay results 4 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Klf1 Mutation: 22 strains or lines available

References

• Original: J:25651 Perkins AC, et al., Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature. 1995 May 25;375(6529):318-22
• All: 21 reference(s)