En1^tm1Alj
Targeted Allele Detail

Summary

• Symbol: En1^tm1Alj
• Name: engrailed 1; targeted mutation 1, Alexandra L Joyner
• MGI ID: MGI:1857163
• Synonyms: En-1^hd
• Gene: En1 Location: Chr1:120530246-120535719 bp, + strand Genetic Position: Chr1, 52.74 cM, cytoband C2-qter
• Alliance: En1^tm1Alj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:19212
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin selection cassette replaced 0.85 kb of exon 2, which encodes part of the homeobox domain. (J:19212)

Expression

In Mice Carrying this Mutation:	146 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any En1 Mutation: 34 strains or lines available

References

• Original: J:19212 Wurst W, et al., Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development. 1994 Jul;120(7):2065-75
• All: 28 reference(s)