En2^tm1Alj
Targeted Allele Detail

Summary

• Symbol: En2^tm1Alj
• Name: engrailed 2; targeted mutation 1, Alexandra L Joyner
• MGI ID: MGI:1857164
• Synonyms: En2-, en-2^hd
• Gene: En2 Location: Chr5:28370692-28377164 bp, + strand Genetic Position: Chr5, 13.94 cM
• Alliance: En2^tm1Alj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67524
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 1 kb of sequence containing 300 bp of intron and 700 bp of the homeobox exon. (J:67524)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	28 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any En2 Mutation: 104 strains or lines available

References

• Original: J:67524 Joyner AL, et al., Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science. 1991 Mar 8;251(4998):1239-43
• All: 41 reference(s)