Fcer1g^tm1Rav
Targeted Allele Detail

Summary

• Symbol: Fcer1g^tm1Rav
• Name: Fc receptor, IgE, high affinity I, gamma polypeptide; targeted mutation 1, Jeffrey V Ravetch
• MGI ID: MGI:1857165
• Synonyms: Fcepsilonrgamma^-, Fcer1g^tm1, Fcer1g^tm1Ra, Fcerg1^tm1, FcgammaR-, FcR-, FcRg^-, FcR gamma^-, FcRgamma-, FcRgammac^-, FcRgamma-chain^-, FcRgamma^nl, FcRKO, gamma-
• Gene: Fcer1g Location: Chr1:171057141-171061918 bp, - strand Genetic Position: Chr1, 79.23 cM
• Alliance: Fcer1g^tm1Rav page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39248
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette was inserted into exon 2, creating a new stop codon 239 bp downstream of the integration site. RT-PCR analysis on RNA isolated from activated macrophages, mast cells and NK cells of homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on lysates derived from activated macrophages, mast cells and NK cells of homozygous mice confirmed that no protein is encoded by this allele. (J:39248)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 8 strains available Cell Lines: 0 lines available
• Carrying any Fcer1g Mutation: 28 strains or lines available

References

• Original: J:39248 Takai T, et al., FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell. 1994 Feb 11;76(3):519-29
• All: 380 reference(s)