Fcgr2b^tm1Ttk
Targeted Allele Detail

Summary

• Symbol: Fcgr2b^tm1Ttk
• Name: Fc receptor, IgG, low affinity IIb; targeted mutation 1, Toshiyuki Takai
• MGI ID: MGI:1857166
• Synonyms: FcgammaRII, FcgammaRII-, FcgammaRII2B-, FcgammaRIIb^-, FcgammaRIIB^-, Fcgr2b^tm1Rav, FcgRIIB129^-, FcRIIB^-, IIB-, TAC264
• Gene: Fcgr2b Location: Chr1:170786186-170804116 bp, - strand Genetic Position: Chr1, 78.02 cM
• Alliance: Fcgr2b^tm1Ttk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31133
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.3 kb genomic fragment containing the S1 and EC1 exons was replaced by a neomycin resistance cassette. Encoded transcript was undetectable in homozygous mutant mice via Northern blot analysis (data not shown). Western blot analysis of LPS-stimulated B cells derived from homozygous mice confirmed that no protein was made from this allele, and FACS analysis demonstrated that no functional protein was expressed on the cell surface of B cells in homozygous mice. (J:31133)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Fcgr2b Mutation: 49 strains or lines available

References

• Original: J:31133 Takai T, et al., Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature. 1996 Jan 25;379(6563):346-9
• All: 264 reference(s)