Alox5ap^tm1Jdm
Targeted Allele Detail

Summary

• Symbol: Alox5ap^tm1Jdm
• Name: arachidonate 5-lipoxygenase activating protein; targeted mutation 1, John D McNeish
• MGI ID: MGI:1857167
• Synonyms: FLAP, FLAP -
• Gene: Alox5ap Location: Chr5:149201814-149224963 bp, + strand Genetic Position: Chr5, 89.18 cM, cytoband G3
• Alliance: Alox5ap^tm1Jdm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29897
• Parent Cell Line: DBA-252 (ES Cell)
• Strain of Origin: DBA/1LacJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A PGK-neomycin selection cassette was inserted into coding sequences of the gene. (J:29897)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Alox5ap Mutation: 15 strains or lines available

Notes

Development of a DBA/1LacJ ES cell line enables gene targeting directly on the arthritis-susceptible background, as 129 ES cell lines generate mice that are not susceptible to collagen-induced arthritis (J:29897).

References

• Original: J:29897 Roach ML, et al., A new embryonic stem cell line from DBA/1lacJ mice allows genetic modification in a murine model of human inflammation. Exp Cell Res. 1995 Dec;221(2):520-5
• All: 3 reference(s)