Fos^tm1Pa
Targeted Allele Detail

Summary

• Symbol: Fos^tm1Pa
• Name: FBJ osteosarcoma oncogene; targeted mutation 1, Virginia E Papaioannou
• MGI ID: MGI:1857171
• Synonyms: c-fos-
• Gene: Fos Location: Chr12:85520664-85524047 bp, + strand Genetic Position: Chr12, 39.7 cM
• Alliance: Fos^tm1Pa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:3233
• Parent Cell Line: PJ5 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 1 was disrupted by the insertion of a neomycin selection cassette. Northern blot analysis showed an absence of transcript in homozygous mutant mice. (J:70953)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fos Mutation: 43 strains or lines available

References

• Original: J:3233 Johnson RS, et al., Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell. 1992 Nov 13;71(4):577-86
• All: 32 reference(s)