Fyn^tm1Sor
Targeted Allele Detail

Summary

• Symbol: Fyn^tm1Sor
• Name: Fyn proto-oncogene; targeted mutation 1, Philippe Soriano
• MGI ID: MGI:1857172
• Synonyms: fyn^-
• Gene: Fyn Location: Chr10:39245735-39441377 bp, + strand Genetic Position: Chr10, 20.51 cM
• Alliance: Fyn^tm1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:2242
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of a 3kb fragment containing the first coding exon of the gene with a neomycin cassette. (J:2242, J:97095)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Fyn Mutation: 39 strains or lines available

References

• Original: J:2242 Stein PL, et al., pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell. 1992 Sep 4;70(5):741-50
• All: 168 reference(s)