Gabra6^tm1Geh
Targeted Allele Detail

Summary

• Symbol: Gabra6^tm1Geh
• Name: gamma-aminobutyric acid type A receptor subunit alpha 6; targeted mutation 1, Gregg E Homanics
• MGI ID: MGI:1857173
• Gene: Gabra6 Location: Chr11:42197264-42211899 bp, - strand Genetic Position: Chr11, 25.03 cM
• Alliance: Gabra6^tm1Geh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40242
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 8. Northern blot analysis on RNA derived from cerebellum of homozygous mice demonstrated that aberrant transcripts were expressed from this allele. Hoever, none of these are predicted to be able to code for a functional protein (J:40242). Later studies showed that this mutation also affected the expression of the Gabra1 and Gabrb2 genes (J:63792). (J:40242, J:63792)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gabra6 Mutation: 39 strains or lines available

References

• Original: J:40242 Homanics GE, et al., Gene knockout of the alpha6 subunit of the gamma-aminobutyric acid type A receptor: lack of effect on responses to ethanol, pentobarbital, and general anesthetics. Mol Pharmacol. 1997 Apr;51(4):588-96
• All: 3 reference(s)