Gja1^tm1Kdr
Targeted Allele Detail

Summary

• Symbol: Gja1^tm1Kdr
• Name: gap junction protein, alpha 1; targeted mutation 1, Gerald M Kidder
• MGI ID: MGI:1857177
• Synonyms: Cx43-, Cx43aplha1KO, Cx43 KO
• Gene: Gja1 Location: Chr10:56253297-56266519 bp, + strand Genetic Position: Chr10, 28.64 cM
• Alliance: Gja1^tm1Kdr page

E16.5 and E18.5 Gja1^tm1Kdr/Gja1^tm1Kdr skulls are hypomineralized

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:24121
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A promoterless neomycin gene was inserted in-frame into exon 2. (J:24121)

Expression

In Mice Carrying this Mutation:	98 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	25 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Gja1^tm1Kdr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gja1 Mutation: 60 strains or lines available

References

• Original: J:24121 Reaume AG, et al., Cardiac malformation in neonatal mice lacking connexin43 [see comments]. Science. 1995 Mar 24;267(5205):1831-4
• All: 101 reference(s)