Hbb^tm1Unc
Targeted Allele Detail

Summary

• Symbol: Hbb^tm1Unc
• Name: hemoglobin beta chain complex; targeted mutation 1, University of North Carolina
• MGI ID: MGI:1857179
• Synonyms: Hbb^th2
• Gene: Hbb Location: unknown Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:4932
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 2 of the beta1 gene. No protein for the targeted gene was detected via cellulose electrophoresis of hemoglobin from homozygous mutant mice. (J:4932)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hbb Mutation: 47 strains or lines available

References

• Original: J:4932 Shehee WR, et al., Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3177-81
• All: 2 reference(s)