Lipc^tm1Unc
Targeted Allele Detail

Summary

• Symbol: Lipc^tm1Unc
• Name: lipase, hepatic; targeted mutation 1, University of North Carolina
• MGI ID: MGI:1857182
• Synonyms: hl^-, HL-deficient
• Gene: Lipc Location: Chr9:70705410-70859503 bp, - strand Genetic Position: Chr9, 39.57 cM
• Alliance: Lipc^tm1Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22938
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance cassette was inserted into exon 4 of the gene. (J:22938)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Lipc Mutation: 37 strains or lines available

References

• Original: J:22938 Homanics GE, et al., Mild dyslipidemia in mice following targeted inactivation of the hepatic lipase gene. J Biol Chem. 1995 Feb 17;270(7):2974-80
• All: 35 reference(s)