Ifng^tm1Ts
Targeted Allele Detail

Summary

• Symbol: Ifng^tm1Ts
• Name: interferon gamma; targeted mutation 1, Timothy Stewart
• MGI ID: MGI:1857184
• Synonyms: gko, GKO, ifg^tm1, ifng^-, IFN-gamma-, IFNgamma-, IFN-gamma KO, IFN-gammaKO, IFNgamma KO, IFN-gamma^tm1Ts, IFN-g KO, Ifng^tm1Ts, Ifn-g^tm1Ts, Ifngtm1Ts, ifn^tm1Ts, Ifn^tm/Ts
• Gene: Ifng Location: Chr10:118276951-118281797 bp, + strand Genetic Position: Chr10, 66.75 cM
• Alliance: Ifng^tm1Ts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66802
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin gene into exon 2, which introduced a termination codon after the first 30 amino acids of the mature protein. (J:66802)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ifng^tm1Ts

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 18 strains available Cell Lines: 0 lines available
• Carrying any Ifng Mutation: 49 strains or lines available

References

• Original: J:66802 Dalton DK, et al., Multiple defects of immune cell function in mice with disrupted interferon-gamma genes [see comments]. Science. 1993 Mar 19;259(5102):1739-42
• All: 1225 reference(s)