Igha^tm1Grh
Targeted Allele Detail

Summary

• Symbol: Igha^tm1Grh
• Name: immunoglobulin heavy constant alpha; targeted mutation 1, Gregory Harriman
• MGI ID: MGI:1857185
• Synonyms: IgA -
• Gene: Igha Location: Chr12:113219824-113223856 bp, - strand Genetic Position: Chr12, 62.09 cM
• Alliance: Igha^tm1Grh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53217
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the Ialpha exon, the entire IgA switch region and the 5' half of the Calpha region. (J:53217)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Igha Mutation: 18 strains or lines available

References

• Original: J:53217 Harriman GR, et al., Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes. J Immunol. 1999 Mar 1;162(5):2521-9
• All: 44 reference(s)