Ighd^tm1Cgn
Targeted Allele Detail

Summary

• Symbol: Ighd^tm1Cgn
• Name: immunoglobulin heavy constant delta; targeted mutation 1, University of Cologne
• MGI ID: MGI:1857186
• Synonyms: Cdelta, deltaT, IgD-deficient
• Gene: Ighd Location: Chr12:113371155-113379944 bp, - strand Genetic Position: Chr12, 62.1 cM
• Alliance: Ighd^tm1Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64281
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a large part of the first exon and inserted a frameshift into the third exon of the constant region of the gene. (J:64281)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ighd Mutation: 19 strains or lines available

References

• Original: J:64281 Roes J, et al., Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells. J Exp Med. 1993 Jan 1;177(1):45-55
• All: 5 reference(s)