Igkc^tm1Cgn
Targeted Allele Detail

Summary

• Symbol: Igkc^tm1Cgn
• Name: immunoglobulin kappa constant; targeted mutation 1, University of Cologne
• MGI ID: MGI:1857188
• Synonyms: CkappaT, kappa-
• Gene: Igkc Location: Chr6:70703419-70703738 bp, + strand Genetic Position: Chr6, 32.04 cM, cytoband C
• Alliance: Igkc^tm1Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64287
• Parent Cell Line: BL/6-III (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the exon encoding the constant region of the immunoglobulin kappa chain, its splicing signal and polyadenylation site. (J:64287, J:261505)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Igkc Mutation: 9 strains or lines available

References

• Original: J:64287 Zou YR, et al., Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa. EMBO J. 1993 Mar;12(3):811-20
• All: 14 reference(s)