Il2^tm1Hor
Targeted Allele Detail

Summary

• Symbol: Il2^tm1Hor
• Name: interleukin 2; targeted mutation 1, Ivan Horak
• MGI ID: MGI:1857191
• Synonyms: Il2-, IL-2-, IL-2 KO, IL-2^null
• Gene: Il2 Location: Chr3:37174862-37180103 bp, - strand Genetic Position: Chr3, 18.3 cM, cytoband B-C
• Alliance: Il2^tm1Hor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39989
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin-resistance gene into the third exon introduced several stop codons in all reading frames. (J:39989)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

22 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Il2^tm1Hor

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Il2 Mutation: 43 strains or lines available

References

• Original: J:39989 Schorle H, et al., Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature. 1991 Aug 15;352(6336):621-4
• All: 195 reference(s)