Il2ra^tm1Dw
Targeted Allele Detail

Summary

• Symbol: Il2ra^tm1Dw
• Name: interleukin 2 receptor, alpha chain; targeted mutation 1, Dennis M Willerford
• MGI ID: MGI:1857192
• Synonyms: CD25^-, CD25KO, IL-2Ralpha-, IL2Ralpha^-, IL-2Ralpha KO
• Gene: Il2ra Location: Chr2:11647618-11698004 bp, + strand Genetic Position: Chr2, 8.91 cM, cytoband A2-A3
• Alliance: Il2ra^tm1Dw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64279
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 5.5 kb segment of the gene, containing exons 2 and 3, which encode for the binding site of the protein. (J:64279)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Il2ra Mutation: 51 strains or lines available

References

• Original: J:64279 Willerford DM, et al., Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 1995 Oct;3(4):521-30
• All: 84 reference(s)