Il2rb^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Il2rb^tm1Mak
• Name: interleukin 2 receptor, beta chain; targeted mutation 1, Tak Mak
• MGI ID: MGI:1857193
• Synonyms: 2Rbeta-, CD122^-, IL-2/IL-15Rbeta-, Il2rb^-, IL-2Rbeta-
• Gene: Il2rb Location: Chr15:78363456-78379471 bp, - strand Genetic Position: Chr15, 37.52 cM, cytoband E
• Alliance: Il2rb^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25940
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a neomycin resistance cassette disrupted exon 6 of the gene, which encodes a region of extracellular domain proximal to the transmembrane region of the protein. (J:25940)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Il2rb Mutation: 45 strains or lines available

Notes

Mice were generated from two independent embryonic stem cell lines: D3, derived from 129S2/SvPas; and E14, derived from 129P2/OlaHsd. (J:25940) Experiments described in J:25940 were performed using mice derived from the D3 ES cell line.

References

• Original: J:25940 Suzuki H, et al., Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science. 1995 Jun 9;268(5216):1472-6
• All: 67 reference(s)