Il4^tm1Nnt
Targeted Allele Detail

Summary

• Symbol: Il4^tm1Nnt
• Name: interleukin 4; targeted mutation 1, Nancy Noben-Trauth
• MGI ID: MGI:1857196
• Synonyms: il4^-, IL-4-
• Gene: Il4 Location: Chr11:53503287-53509492 bp, - strand Genetic Position: Chr11, 31.97 cM
• Alliance: Il4^tm1Nnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37196
• Parent Cell Line: BL/6-III (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance cassette was inserted into exon 3 of the gene. (J:36386)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il4 Mutation: 46 strains or lines available

References

• Original: J:37196 Metwali A, et al., The granulomatous response in murine Schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice. J Immunol. 1996 Nov 15;157(10):4546-53
• All: 75 reference(s)