Il6^tm1Kopf
Targeted Allele Detail

Summary

• Symbol: Il6^tm1Kopf
• Name: interleukin 6; targeted mutation 1, Manfred Kopf
• MGI ID: MGI:1857197
• Synonyms: Il6-, IL-6-, IL-6 KO, Il6^tm1Koe, Il6^tm1Kopf
• Gene: Il6 Location: Chr5:30218112-30224973 bp, + strand Genetic Position: Chr5, 15.7 cM
• Alliance: Il6^tm1Kopf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17360
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 2. RT-PCR experiments on RNA derived from LPS-stimulated macrophages of homozygous mice demonstrated that no detectable transcript was produced from this allele. ELISA and bioassay experiments confirmed that no functional protein was made in homozygous mice. (J:17360)

Disease models

Expression

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	20 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Il6^tm1Kopf

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 9 strains available Cell Lines: 0 lines available
• Carrying any Il6 Mutation: 38 strains or lines available

References

• Original: J:17360 Kopf M, et al., Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature. 1994 Mar 24;368(6469):339-42
• All: 707 reference(s)