Il12a^tm1Jm
Targeted Allele Detail

Summary

• Symbol: Il12a^tm1Jm
• Name: interleukin 12a; targeted mutation 1, Jeanne Magram
• MGI ID: MGI:1857200
• Synonyms: Il12a-, Il12p35^-, IL-12p35, IL-12p35^-, p35-
• Gene: Il12a Location: Chr3:68597977-68605880 bp, + strand Genetic Position: Chr3, 31.92 cM
• Alliance: Il12a^tm1Jm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34164
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced exons 1 and 2 of the gene. (J:34164)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il12a Mutation: 35 strains or lines available

References

• Original: J:34164 Mattner F, et al., Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur J Immunol. 1996 Jul;26(7):1553-9
• All: 201 reference(s)