Il12b^tm1Jm
Targeted Allele Detail

Summary

• Symbol: Il12b^tm1Jm
• Name: interleukin 12b; targeted mutation 1, Jeanne Magram
• MGI ID: MGI:1857201
• Synonyms: IL-12^-, Il-12/23p40 KO, Il12b-, IL-12b^{tm1 Jm}, IL-12KO, IL-12 p40-, IL-12p40-, IL-12p40^-, IL12p40-, IL-12p40-KO, p40-
• Gene: Il12b Location: Chr11:44290890-44304860 bp, + strand Genetic Position: Chr11, 25.94 cM, cytoband A5-B2
• Alliance: Il12b^tm1Jm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33141
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced a portion of exon 3 of the gene. (J:33141)

Expression

In Mice Carrying this Mutation:	32 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Il12b Mutation: 33 strains or lines available

References

• Original: J:33141 Magram J, et al., IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity. 1996 May;4(5):471-81
• All: 369 reference(s)