Inha^tm1Bay
Targeted Allele Detail

Summary

• Symbol: Inha^tm1Bay
• Name: inhibin alpha; targeted mutation 1, Baylor College of Medicine
• MGI ID: MGI:1857202
• Synonyms: INH^-, Inha^-, inha^m1, Inha^tm1Zuk
• Gene: Inha Location: Chr1:75483872-75487010 bp, + strand Genetic Position: Chr1, 39.16 cM, cytoband C5
• Alliance: Inha^tm1Bay page

Liver and stomach histology of Inha^tm1Bay/Inha^tm1Bay mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:3315
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-hprt expression cassette replaced two exons of the Inha gene. The authors predict that homozygous mutant mice would not synthesize Inha mRNA or protein. (J:3315)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Inha^tm1Bay

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inha Mutation: 9 strains or lines available

References

• Original: J:3315 Matzuk MM, et al., Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature. 1992 Nov 26;360(6402):313-9
• All: 46 reference(s)