Insr^tm1Dac
Targeted Allele Detail

Summary

• Symbol: Insr^tm1Dac
• Name: insulin receptor; targeted mutation 1, Domenico Accili
• MGI ID: MGI:1857204
• Synonyms: Insr-, IR-, IRKO, L1
• Gene: Insr Location: Chr8:3200922-3329649 bp, - strand Genetic Position: Chr8, 1.82 cM
• Alliance: Insr^tm1Dac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33408
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A premature chain termination was introduced downstream from codon 306 of exon 4 of the gene. Western blots of brain extracts from homozygous mutant mice showed no detectable insulin receptor protein. Reverse transcriptase-PCR of RNA isolated from brain, liver and skeletal muscle showed no transcript. (J:33408)

Disease models

Expression

In Mice Carrying this Mutation:	29 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Insr Mutation: 95 strains or lines available

References

• Original: J:33408 Accili D, et al., Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet. 1996 Jan;12(1):106-9
• All: 55 reference(s)