Irf1^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Irf1^tm1Mak
• Name: interferon regulatory factor 1; targeted mutation 1, Tak Mak
• MGI ID: MGI:1857205
• Synonyms: IRF-1^-
• Gene: Irf1 Location: Chr11:53660841-53669200 bp, + strand Genetic Position: Chr11, 32.0 cM
• Alliance: Irf1^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64286
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 1.2 kb region of the gene, which encodes for amino acids 63 - 223, deleting part of the DNA-binding domain of the protein. (J:64286)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Irf1^tm1Mak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf1 Mutation: 21 strains or lines available

References

• Original: J:64286 Matsuyama T, et al., Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell. 1993 Oct 8;75(1):83-97
• All: 142 reference(s)