Itga4^tm1Hyn
Targeted Allele Detail

Summary

• Symbol: Itga4^tm1Hyn
• Name: integrin alpha 4; targeted mutation 1, Richard Hynes
• MGI ID: MGI:1857206
• Synonyms: alpha4KO, alpha4-null
• Gene: Itga4 Location: Chr2:79085770-79163467 bp, + strand Genetic Position: Chr2, 47.38 cM
• Alliance: Itga4^tm1Hyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23140
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 950 bp fragment which contained most of the first exon of the gene. (J:23140)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itga4 Mutation: 62 strains or lines available

References

• Original: J:23140 Yang JT, et al., Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development. 1995 Feb;121(2):549-60
• All: 10 reference(s)