Itga5^tm1Hyn
Targeted Allele Detail

Summary

• Symbol: Itga5^tm1Hyn
• Name: integrin alpha 5 (fibronectin receptor alpha); targeted mutation 1, Richard Hynes
• MGI ID: MGI:1857207
• Synonyms: alpha5-, alpha5-null
• Gene: Itga5 Location: Chr15:103252713-103275190 bp, - strand Genetic Position: Chr15, 58.9 cM
• Alliance: Itga5^tm1Hyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:16248
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced 330 bp of the gene, deleting most of the first exon. (J:16248)

Expression

In Mice Carrying this Mutation:	49 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Itga5^tm1Hyn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itga5 Mutation: 47 strains or lines available

References

• Original: J:16248 Yang JT, et al., Embryonic mesodermal defects in alpha 5 integrin-deficient mice. Development. 1993 Dec;119(4):1093-105
• All: 22 reference(s)