About   Help   FAQ
Itgb2tm1Bay
Targeted Allele Detail
Summary
Symbol: Itgb2tm1Bay
Name: integrin beta 2; targeted mutation 1, Baylor College of Medicine
MGI ID: MGI:1857208
Synonyms: CD18-, CD18hypo, CD18low, Itgb2hypo
Gene: Itgb2  Location: Chr10:77366164-77401542 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Itgb2tm1Bay page
Clinical features and histopathology of psoriasiform skin disease in Itgb2tm1Bay/Itgb2tm1Bay mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:13599
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
 
Mutation detailsAn insertion mutation that duplicates exons 2 and 3 with interruption of one copy of exon 3 with a neomycin cassette. This is not a null mutation but rather a hypomorph expressing very low levels of ITGB2 protein. (J:13599)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Allelic CompositionGenetic BackgroundCell Line(s)
 
hm2  Disease Model
involves: 129S7/SvEvBrd
 
hm3  Disease Model
involves: 129S7/SvEvBrd * C57BL/6J
 
hm4  Disease Model
involves: 129S7/SvEvBrd * C57BL/6J * PL/J
 
hm5  Disease Model
involves: 129S7/SvEvBrd * PL/J
 
involves: 129S7/SvEvBrd * C57BL/6J
 
 
ht8  Disease Model
involves: 129S7/SvEvBrd * C57BL/6J * PL/J
 
ht9  Disease Model
 
 
 
involves: 129S7/SvEvBrd * C57BL/6J * PL/J
 
involves: 129S7/SvEvBrd * C57BL/6J * PL/J
 
involves: 129S7/SvEvBrd * C57BL/6J * PL/J
 
involves: 129S7/SvEvBrd * C57BL/6J * PL/J
 
involves: 129S7/SvEvBrd * C57BL/6J * PL/J
 
involves: C57BL/6J * PL/J
 
involves: C57BL/6J * PL/J
 
Phenotypes:
Affected Systems
show or hide all annotated terms
                                   
cardiovascular system
decreased susceptibility to induced choroidal neovascularization
abnormal retina vasculature morphology
hematopoietic system
myeloid hyperplasia
thrombocytosis
increased leukocyte cell number
increased granulocyte number
increased basophil cell number
increased eosinophil cell number
increased neutrophil cell number
increased lymphocyte cell number
increased T cell number
increased T-helper 1 cell number
increased monocyte cell number
abnormal spleen morphology
abnormal spleen red pulp morphology
abnormal T cell activation
homeostasis/metabolism
increased circulating glucose level
abnormal cytokine level
immune system
myeloid hyperplasia
increased leukocyte cell number
increased granulocyte number
increased basophil cell number
increased eosinophil cell number
increased neutrophil cell number
increased lymphocyte cell number
increased T cell number
increased T-helper 1 cell number
increased monocyte cell number
abnormal spleen morphology
abnormal spleen red pulp morphology
abnormal T cell activation
abnormal cytokine level
enlarged lymph nodes
increased interferon-gamma secretion
rheumatoid arthritis
decreased inflammatory response
dermatitis
integument
N N N
integument phenotype
N N N N N
dermatitis
alopecia
abnormal hair follicle dermal papilla morphology
abnormal dermal layer morphology
mixed cellular infiltration to dermis
abnormal epidermal layer morphology
hyperkeratosis
orthokeratosis
parakeratosis
acanthosis
epidermal hyperplasia
reddish skin
scaly skin
abnormal skin condition
psoriasis
mortality/aging
premature death
nervous system
decreased retina photoreceptor cell number
retina photoreceptor degeneration
pigmentation
N
pigmentation phenotype
N
skeleton
rheumatoid arthritis
vision/eye
decreased susceptibility to induced choroidal neovascularization
abnormal retina morphology
abnormal retina vasculature morphology
decreased retina photoreceptor cell number
retina photoreceptor degeneration
abnormal eye physiology
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Key:
disease model   expected model not found
Models:
Human Diseases
hm2
hm3
hm4
hm5
ht7
ht8
ht9
IDs
IDs
Expression
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb2 Mutation:  50 strains or lines available
References
Original:  J:13599 Wilson RW, et al., Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol. 1993 Aug 1;151(3):1571-8
All:  64 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/17/2024
MGI 6.24
The Jackson Laboratory