Itgb2^tm1Bay
Targeted Allele Detail

Summary

• Symbol: Itgb2^tm1Bay
• Name: integrin beta 2; targeted mutation 1, Baylor College of Medicine
• MGI ID: MGI:1857208
• Synonyms: CD18^-, CD18^hypo, CD18^low, Itgb2^hypo
• Gene: Itgb2 Location: Chr10:77366164-77401542 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Itgb2^tm1Bay page

Clinical features and histopathology of psoriasiform skin disease in Itgb2^tm1Bay/Itgb2^tm1Bay mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:13599
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: An insertion mutation that duplicates exons 2 and 3 with interruption of one copy of exon 3 with a neomycin cassette. This is not a null mutation but rather a hypomorph expressing very low levels of ITGB2 protein. (J:13599)

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itgb2 Mutation: 50 strains or lines available

References

• Original: J:13599 Wilson RW, et al., Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol. 1993 Aug 1;151(3):1571-8
• All: 64 reference(s)