Juntm1Pa
Targeted Allele Detail
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Symbol: |
Juntm1Pa |
Name: |
jun proto-oncogene; targeted mutation 1, Virginia Papaioannou |
MGI ID: |
MGI:1857209 |
Synonyms: |
c-jun null, Jun- |
Gene: |
Jun Location: Chr4:94937273-94940459 bp, - strand Genetic Position: Chr4, 43.34 cM, cytoband C5-C7
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Alliance: |
Juntm1Pa page
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Germline Transmission: |
Earliest citation of germline transmission:
J:13175
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Parent Cell Line: |
PJ5 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: A neomycin resistance cassette was inserted into the 5'-untranslated leader sequence of the gene. Southern blots of fetal tissue from homozygous mutants showed no wild-type allele present. Northern blots of embryonic fibroblasts from homozygous mutants showed no detectable mRNA for the targeted gene.
(J:13175)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | either: (involves: 129S/SvEv * 129X1/SvJ) or (involves: 129X1/SvJ * C57BL/6J) | | | | involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ * C57BL/6J | | | | involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL | |
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Phenotypes: |
Affected Systems |
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cardiovascular system
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N
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cardiovascular system phenotype
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N
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cellular
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√
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decreased fibroblast proliferation
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√
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embryo
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N
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N
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embryo phenotype
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N
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N
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mortality/aging
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√
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embryonic lethality during organogenesis, complete penetrance
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:13175 Johnson RS, et al., A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev. 1993 Jul;7(7B):1309-17 |
All: |
7 reference(s) |
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