Jun^tm1Pa
Targeted Allele Detail

Summary

• Symbol: Jun^tm1Pa
• Name: jun proto-oncogene; targeted mutation 1, Virginia Papaioannou
• MGI ID: MGI:1857209
• Synonyms: c-jun null, Jun^-
• Gene: Jun Location: Chr4:94937273-94940459 bp, - strand Genetic Position: Chr4, 43.34 cM, cytoband C5-C7
• Alliance: Jun^tm1Pa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:13175
• Parent Cell Line: PJ5 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into the 5'-untranslated leader sequence of the gene. Southern blots of fetal tissue from homozygous mutants showed no wild-type allele present. Northern blots of embryonic fibroblasts from homozygous mutants showed no detectable mRNA for the targeted gene. (J:13175)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Jun Mutation: 12 strains or lines available

References

• Original: J:13175 Johnson RS, et al., A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev. 1993 Jul;7(7B):1309-17
• All: 7 reference(s)