Kras^tm1Tyj
Targeted Allele Detail

Summary

• Symbol: Kras^tm1Tyj
• Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 1, Tyler Jacks
• MGI ID: MGI:1857210
• Synonyms: K-ras^-, K-ras^KO, K-ras^tm1
• Gene: Kras Location: Chr6:145162425-145195965 bp, - strand Genetic Position: Chr6, 77.37 cM, cytoband G2
• Alliance: Kras^tm1Tyj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43433
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1 was replaced by a neomycin resistance gene cassette. (J:43433)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Kras^tm1Tyj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kras Mutation: 84 strains or lines available

References

• Original: J:43433 Johnson L, et al., K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 1997 Oct 1;11(19):2468-81
• All: 22 reference(s)