Lifr^tm1Imx
Targeted Allele Detail

Summary

• Symbol: Lifr^tm1Imx
• Name: LIF receptor alpha; targeted mutation 1, Immunex
• MGI ID: MGI:1857213
• Synonyms: LIFR -
• Gene: Lifr Location: Chr15:7120095-7226970 bp, + strand Genetic Position: Chr15, 3.46 cM
• Alliance: Lifr^tm1Imx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25253
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• A lacZ/neomycin cassette replaced the ATG start codon in the targeted construct. (J:25253)

Disease models

Expression

In Mice Carrying this Mutation:	203 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lifr Mutation: 59 strains or lines available

References

• Original: J:25253 Ware CB, et al., Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development. 1995 May;121(5):1283-99
• All: 12 reference(s)