Lrpap1^tm1Her
Targeted Allele Detail

Summary

• Symbol: Lrpap1^tm1Her
• Name: low density lipoprotein receptor-related protein associated protein 1; targeted mutation 1, Joachim Herz
• MGI ID: MGI:1857214
• Synonyms: RAP-
• Gene: Lrpap1 Location: Chr5:35248834-35263043 bp, - strand Genetic Position: Chr5, 18.01 cM
• Alliance: Lrpap1^tm1Her page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43736
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into sequences that encode the leader peptide. Immunoblot analysis of liver and brain did not detect the encoded protein in homozygous animals. (J:43736)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Lrpap1 Mutation: 24 strains or lines available

Notes

ES cell line = JH1 or AB1 (129S7/SvEvBrd-Hprt⁺).

References

• Original: J:43736 Willnow TE, et al., Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4537-41
• All: 14 reference(s)