Lta^tm1Dch
Targeted Allele Detail

Summary

• Symbol: Lta^tm1Dch
• Name: lymphotoxin A; targeted mutation 1, David D Chaplin
• MGI ID: MGI:1857215
• Synonyms: LT-, Lta^-, LT-alpha-, LTalpha-
• Gene: Lta Location: Chr17:35422141-35424327 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Lta^tm1Dch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17976
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a small portion of exon 2, all of exon 3, and a small portion of exon 4. (J:17976, J:95222, J:110548)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lta Mutation: 17 strains or lines available

References

• Original: J:17976 De Togni P, et al., Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin [see comments]. Science. 1994 Apr 29;264(5159):703-7
• All: 181 reference(s)